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2 edition of Modulation of biliary lipid secretion found in the catalog.

Modulation of biliary lipid secretion

Sandra Mary Hamlin

Modulation of biliary lipid secretion

by Sandra Mary Hamlin

  • 149 Want to read
  • 23 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (Ph.D)-University of Birmingham, School of Biochemistry, 1991.

Statementby Sandra Mary Hamlin.
ID Numbers
Open LibraryOL13929213M

The objective of this study was to examine the role of biliary cholesterol secretion in modulating macrophage RCT in Niemann-Pick C1-Like 1 (NPC1L1) liver only (L1(LivOnly)) mice, an animal model. @article{osti_, title = {Biliary lipids, bile acids, and gallbladder function in the human female:effects of contraceptive steroids}, author = {Kern, F., Jr. and Everson, G T and DeMark, B and McKinley, C and Showalter, R and Braverman, D Z and Szczepanik-Van Leeuwen, P and Klein, P D}, abstractNote = {Reported are biliary lipid composition and secretion, bile acid composition and.

Bile Function: Biliary Composition, Role of Bile Acids and Biliary Secretion by Dr. Cameron Troup MD in Digestive System It is a yellow-green fluid that is produced in the liver, stored in the gallbladder and passed through the common bile duct to the duodenum, where it helps digest fat. The nonsurgical management of gallstone disease has drawn widespread clinical interest during the last decade as ultrasound surveys have indicated that cholelithiasis is predom­ inantly an asymptomatic condition and much more prevalent than previously thought. This book presents an overview of the.

Anatomically, the biliary tract is composed of intra-and extrahepatic biliary systems. The major function of biliary system is the secretion and delivery of the bile to the intestine. Experts hear latest on cholesterol gallstones. The gene for Mdr2 P-glycoprotein, a phospholipid flippase, was solely responsible for phospholipid secretion into bile but modulation of biliary cholesterol secretion was multifactorial, they reported. Gustav Paumgartner (University Clinic, Munich, Germany) discussed how medical treatments for Author: Flavio Nervi.


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Modulation of biliary lipid secretion by Sandra Mary Hamlin Download PDF EPUB FB2

The order of effectiveness of the cAMP-elevating agents at decreasing biliary lipid output was CPTcAMP greater than forskolin greater than dbcAMP greater than 8BrcAMP. Biliary output of bile acids was essentially unaltered compared with controls; similarly, no decrease in the secretion of protein and triacylglycerols into the perfusion medium was by: Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues Article (PDF Available) in Biochemical Journal (3) March with 42 Reads How we measure 'reads'.

Modulation of biliary lipid secretion by forskolin and cyclic AMP analogues. By S Hamlin, K Rahman, M Carrella and R Coleman.

Cite. BibTex; Full citation; Publisher: Portland Press Ltd. Year: DOI identifier: /bj OAI identifier: Provided by: MUCC (Crossref) Author: S Hamlin, K Rahman, M Carrella and R Coleman. In addition to the above-discussed modulation of the influence of hamster LDL infusion on bile flow by CDC and UDC feeding, the treatment with these two bile acids affected both bile flow during normal saline infusion and biliary cholesterol secretion during the LDL by: In cholesterol gallstone disease, mean bile salt (+ lecithin) secretion rates are subnormal and/or mean cholesterol secretion rates are supranormal, especially in the fasting state.

If individuals are obese there is also enhanced hypersecretion of biliary by: Modulation of biliary lipid secretion book The maximal biliary secretion of phospholipids in bilirubin-infused animals, with or without taurocholate administration, was similar to that of the controls, but bile acid secretions more than two-fold that of the controls were required to reach half the maximal biliary phospholipid by: 4.

Biliary cholesterol represents one of the two major excretory pathways for sterol elimination from the body and plays a central role in cholesterol gallstone formation. Biliary cholesterol originates from a precursor pool of preformed and newly synthesized free by: The principal driving forces for biliary lipid secretion are ATP binding cassette (ABC) transporters located on the canalicular membrane of the hepatocyte.

ABCB11 is the dedicated common bile salt export pump (13, 14). The relationship between bile salt secretion and both cholesterol and phospholipid secretion is by: GASTROENTEROLOGY Modulation of the Stimulatory Effect of Pregnenolonea-carbonitrile on Biliary Cholesterol Output in the Rat by Manipulation of the Rate of Hepatic Cholesterol Synthesis STEPHEN D.

TURLEY and JOHN M. DIETSCHY Department of Internal Medicine, University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas, Texas In female rats Cited by: cholesterol secretion from to ~mole per hr.

Over this range of lipid secretion rates, the lipid composition of bile was independent of the rate of bile acid secretion, i.e., phospholipid to bile acid, cholesterol to bile acid, and cholesterol to phospholipid ratios showed no correla­ tion with the rate of bile acid secretion.

Abstract. The processes of biliary lipid secretion are complex and many details are still unknown. This article explores the coupling between bile acid secretion and biliary lipid secretion, and discusses the supply and control of lipid to replenish this biliary lipid by: The analysis of cholesterol, bile acids and phospholipids in fasting gallbladder bile has given useful information on biliary lipid composition.

With this method it has been demonstrated that cholesterol gallstones in man are frequently associated with supersaturated bile, i.e. bile that contains more cholesterol than can be solubilized by the Author: K.

von Bergmann. Biliary cholesterol secretion is important for 2 major disease complexes, atherosclerotic CVD and cholesterol gallstone disease.

Research thus far has provided valuable understanding of the regulation of biliary cholesterol secretion. Secretion of Bile and the Role of Bile Acids In Digestion.

Bile is a complex fluid containing water, electrolytes and a battery of organic molecules including bile acids, cholesterol, phospholipids and bilirubin that flows through the biliary tract into the small intestine.

There are two fundamentally important functions of bile in all species. Effect of continuous and discontinuous infusion of taurocholate on biliary phospholipid secretion. Biochem J. Mar 1; (2)– [PMC free article] Rahman K, Coleman R.

Selective biliary lipid secretion at low bile-salt-output rates in the isolated perfused rat liver. Effects of phalloidin. Biochem J. Jul 1; (1)– biliary lipid secretion is enhanced and the resulting bile has reduced concentrations of cholesterol and lecithin relative to bile salts.

While these observations support the concept of a homeostatic relationship between the enterohepatic flux of bile salts and the secretion of biliary lipids. Biliary cholesterol secretion helps maintain cholesterol homeostasis; it is regulated by the cholesterol exporter adenosine triphosphate–binding cassettes G5 and G8 (ABCG5/G8) and the cholesterol importer Niemann–Pick C1-like 1 (NPC1L1).

We studied another putative regulator of cholesterol secretion into bile, Niemann–Pick C2 (NPC2)—a cholesterol-binding protein secreted by the biliary system—and determined its effects on transporter-mediated biliary secretion Cited by: The major functions of bile acids include: (1) Inducing bile flow and hepatic secretion of biliary lipids (phospholipid and cholesterol).

The active vectorial movement of bile acids from blood to the bile canaliculus creates an osmotic gradient, allowing water and small solutes to enter the biliary Cited by: Vol.

4, No. 5, Suppl. BILIARY LIPID SECRETION 33s, I I I I 0 8fL E SALT SECRETION bmofes/hrl FIG. Influence of BS secretion rates on L and Ch secretion rates in man. [Reprinted from (3) with permission of Raven Press.] secretion on BS by: biliary cholesterol secretion (24), but it is uncertain ifcholes-terol derived from specific lipoproteins or chylomicron rem-nantsmaydirectly drive biliary cholesterol output.

The aim ofthe present investigation was to ascertain if biliary cholesterol output can be directly-influenced by the. lipid transport. Biliary lipid secretion and bile flow were significantly inhibited by both blocking agents at all concentrations.

The selective effect on phospholipid and cholesterol output, however, was greater than for either bile acids or flow. These data support the concept that biliary lipids are secreted by a heterogeneous and complex.Groningen Yellow rats express a genetic defect in the biliary secretion of various organic anions.

During a 5‐hr period after interruption of the enterohepatic circulation, bile acid secretion decreased from ± to ± μmol per 30 min in normal control rats and from ± Cited by: Biliary Lipid Secretion and Bile Composition after Acute and Chronic Interruption of the Enterohepatic Circulation in the Rhesus Monkey IV.

PRIMATE BILIARYPHYSIOLOGY R. HERMONDOWLING,EBERHARDMACK, FromtheDepartmentsof MedicineandSurgery, Boston University Schoolof Medicine, Boston, Massachusetts ABS TRACT Bile salts and phospholipids are both required to solubilize biliary.